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As a leading authority in LDL-C-mediated CV risk reduction, can you provide us with your perspective on the evidence for PCSK9 inhibitors as a foundational approach for managing a broad spectrum of patients with high risk coronary heart disease?

As a leading authority in LDL-C-mediated CV risk reduction, can you provide us with your perspective on the evidence for PCSK9 inhibitors as a foundational approach for managing a broad spectrum of patients with high risk coronary heart disease?

What other markers, besides LDL-C levels, do you believe we should consider to refine CV risk stratification?

What other markers, besides LDL-C levels, do you believe we should consider to refine CV risk stratification?

Can you drill down into the specific results of the ODYSSEY Outcomes Trial that demonstrate unique, significant reductions in associated all-cause mortality and how these findings might be relevant to the interventional cardiologist?

Can you drill down into the specific results of the ODYSSEY Outcomes Trial that demonstrate unique, significant reductions in associated all-cause mortality and how these findings might be relevant to the interventional cardiologist?

How do you identify “progressing patients” with high CV risk in whom PCSK9 therapy represents a game-changing strategy?

How do you identify “progressing patients” with high CV risk in whom PCSK9 therapy represents a game-changing strategy?

From the view of an interventional cardiologist and a lipid medicine/atherosclerosis specialist, can you discuss what LDL-C thresholds vs. clinical burden/clinical history thresholds are important for patient selection for PCSK9-based risk reduction?

From the view of an interventional cardiologist and a lipid medicine/atherosclerosis specialist, can you discuss what LDL-C thresholds vs. clinical burden/clinical history thresholds are important for patient selection for PCSK9-based risk reduction?

What has been your experience with respect to patient satisfaction, discontinuation rates and toleration of this injection-based approach to LDL-C management?

What has been your experience with respect to patient satisfaction, discontinuation rates and toleration of this injection-based approach to LDL-C management?

In light of the recent results showing a reduction in associated all-cause mortality in the ODYSSEY Outcomes Trial, which patients deserve our greatest attention to optimize the translational impact of this study?

In light of the recent results showing a reduction in associated all-cause mortality in the ODYSSEY Outcomes Trial, which patients deserve our greatest attention to optimize the translational impact of this study?

Can you discuss the importance of the two principal PSCK9 CV outcome trials—ODYSSEY Outcomes and FOURIER—and how they are similar and in what ways they are different? What are the implications for the patient with T2D and ASCVD?

Can you discuss the importance of the two principal PSCK9 CV outcome trials—ODYSSEY Outcomes and FOURIER—and how they are similar and in what ways they are different? What are the implications for the patient with T2D and ASCVD?

Based on ODYSSEY Outcomes, which patients in an interventional cardiology practice do you believe will benefit most from PCSK9 inhibition?

Based on ODYSSEY Outcomes, which patients in an interventional cardiology practice do you believe will benefit most from PCSK9 inhibition?

What unique aspects, with respect to all-cause mortality outcomes and baseline LDL-C levels, were observed in the ODYSSEY Outcomes Trial and how would you translate these results into patient care?

What unique aspects, with respect to all-cause mortality outcomes and baseline LDL-C levels, were observed in the ODYSSEY Outcomes Trial and how would you translate these results into patient care?

Since both PCSK9 outcome trials demonstrated impressive safety when LDL-C levels are lowered into ranges much lower than 70 mg/dL, what should be the approach of the interventional and medical cardiologist to achieving LDL-C levels in this range?

Since both PCSK9 outcome trials demonstrated impressive safety when LDL-C levels are lowered into ranges much lower than 70 mg/dL, what should be the approach of the interventional and medical cardiologist to achieving LDL-C levels in this range?

How has our knowledge of the safety and efficacy of PCSCK9 inhibitors evolved, and how has the ODYSSEY Outcomes “treat-to-target” trial helped us translate these advances into the front lines of interventional cardiology practice?

How has our knowledge of the safety and efficacy of PCSCK9 inhibitors evolved, and how has the ODYSSEY Outcomes “treat-to-target” trial helped us translate these advances into the front lines of interventional cardiology practice?

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